Ye Xiong, PhD

Henry Ford Content Links
Laboratory of Traumatic Brain Injury

Biography 

• M.D., Medicine, The Third Military Medical University, Chongqing, P.R. China 1985
• M.S., Biochemistry/Trauma, The Third Military Medical University, Chongqing, P.R. China 1988
• Ph.D., Biochemistry/Trauma, The Third Military Medical University, Chongqing, P.R. China 1994
• Postdoctoral Fellow, Biochemistry and Molecular Biology, School of Medicine, Wayne State University, Detroit, MI 1994-2000
• Research Associate, Institute of Environmental Health Sciences, Wayne State University, Detroit, MI 2000-2005

Professional Societies

National Neurotrauma Society
Society for Neuroscience

Honors/Awards

• Best Undergraduate Student Award, Third Military Medical University, China 1981-1983
• Best Internship Award, 301 General Hospital of Chinese Army, Beijing, China 1985
• Best Graduate Student Award, Third Military Medical University, China 1986-87
• Awards for Achievement in Science and Technology (2nd place), Department of General Logistics, Chinese Army, China 1992, 1997, 1999
• Principal Investigator: National Natural Science Foundation of China (Grant No.39370692): “Role of Mitochondria in Cardiac Dysfunction Induced by Combined Radiation-Burn Injury” 1994-1998

Selected Publications

• Chen Z, Xiong Y, Lou S and Shu C. Lipid peroxidation of mitochondrial membrane induced by D1: an organic solvent extractable component isolated from a crude extract of burn eschar. Burns (London) 22: 369-375, 1996.
• Xiong Y, Peterson PL, Muizelaar JP and Lee CP. Amelioration of mitochondrial function by a novel antioxidant U-101033E following traumatic brain injury in rats. J. Neurotrauma 14: 907-917, 1997.
  Zhao C, Xiong Y, and Shici H. Acetaminophen cytotoxicity in mouse eye: mitochondria in anterior tissues are the primary target. J. Ocular Pharmacol. 13: 269-276, 1997.
• Xiong Y, Gu Q, Peterson PL, Muizelaar JP and Lee CP. Mitochondrial dysfunction and calcium perturbation induced by traumatic brain injury. J. Neurotrauma 14: 23-24, 1997.
• Xiong Y, Peterson PL, Verweij BH, Vinas FC, Muizelaar JP and Lee CP. Mitochondrial dysfunction following experimental traumatic brain injury: Combined efficacy of SNX-111 and U-101033E. J. Neurotrauma 15: 531-544, 1998.
• Xiong Y, Peterson PL, and Lee CP. Effect of N-acetylcysteine on mitochondrial function following traumatic brain injury in rats. J. Neurotrauma 16: 1067-1082, 1999.
• Verweij BH, Muizelaar JP, Vinas FC, Xiong Y, and Lee CP. Impaired cerebral mitochondrial function after traumatic brain injury in humans. J. Neurosurg. 93: 815-820, 2000.
• Verweij BH, Muizelaar JP, Vinas FC, Peterson PL, Xiong Y, and Lee CP. Improvement in mitochondrial dysfunction as a new surrogate efficiency measure for preclinical trials: dose-response and time-window profiles for administration of the calcium channel blocker Ziconotide in experimental brain injury. J. Neurosurg. 93: 829-834, 2000.
• Xiong Y, Lin H, Chen B, Peterson PL and Lee CP. Appearance of shortened Bcl-2 and Bax proteins and lack of evidence for apoptosis in rat forebrain after severe experimental traumatic brain injury. Biochem. Biophys. Res. Comm. 286: 401-405, 2001.
• Xiong Y, Shie FS, Zhang J, Lee CP and Ho YS. The protective role of cellular glutathione peroxidase against trauma-induced mitochondrial dysfunction in mouse brain. J Stroke Cerebrovas Dis 13: 129-137, 2004.
• Ho YS, Xiong Y, Ma W, Spector A and Ho DS. Mice lacking catalase develop normally but show differential sensitivity to oxidant tissue injury. J Biol. Chem. 279: 32804-32812, 2004.
• Xiong Y, Shie F-S, Zhang J, Lee CP, and Ho YS. Prevention of mitochondrial dysfunction in post-traumatic mouse brain by superoxide dismutase. J. Neurochemistry 95:732-744, 2005.
• Xiong Y, Liu X, Lee CP, Chua BHL and Ho Y-S. Attenuation of doxorubin-induced contractile and mitochondrial dysfunction in mouse heart by cellular glutathione peroxidase. Free Rad Biol. Med. 41:46-55, 2006.
• Kowluru RA, Kowluru V, Xiong Y, and Ho YS. Overexpression of mitochondrial superoxide dismutase in mice protects the retina from diabetes-induced oxidative stress. Free Rad Biol. Med. 41:1191-1196, 2006.
• Lin HH, Xiong Y, Ho Y-S, Nguyen H-V, Deng H., Lee R, Yen Y, Z Borok, and Ann D K. Transcriptional regulation by targeted expression of architectural transcription factor high mobility group A2 in salivary glands of transgenic mice. J Oral Sci. 115:30-39, 2007.
• Chua C, Gao J, Ho Y-S, Xiong Y, Xu X, Chen Z, Hamdy R, and Chua B. Overexpression of IAP-2 attenuates apoptosis and protects against myocardial ischemia/reperfusion injury in transgenic mice. Biochem. Biophys. Acta 1773: 577-583, 2007.
• Ho H-S, Xiong Y, Ho D-S, Gao J, Chua BHL, Pai H, Mieyal JJ. Targeted disruption of the glutaredoxin 1 gene does not sensitize adult mice to tissue injury induced by ischemia/reperfusion and hyperoxia. Free Rad. Biol. Med. 43: 1299-1312, 2007.
• Xiong Y, Mahmood A, Lu D, Qu C, Goussev A, Schallert T, and Chopp M. Role of gender in outcome after traumatic brain injury and therapeutic effect of erythropoietin in mice. Brain Res. 1185: 301-312, 2007.
• Wu H, Lu D, Jiang H, Xiong Y, Qu C, Li B, Mahmood A, Zhou D, Chopp M. Simvastatin improves the neurological function after traumatic brain injury through the upregulation of VEGF and BDNF, activation of PI3K/Akt pathway and increase of neurogenesis. J Neurotrauma 25: 130-139, 2008.
• Xiong Y, Lu D, Qu C, Goussev A, Schallert T, Mahmood A, and Chopp M. Effects of erythropoietin on reducing brain damage and improving functional outcome following traumatic brain injury in mice. J Neurosurg. 109: 510-521, 2008.
• Wu H, Lu D, Jiang H, Xiong Y, Qu C, Li B, Mahmood A, Zhou D, Chopp M. Simvastatin-Mediated Upregulation of VEGF and BDNF, Activation of the PI3K/Akt Pathway, and Increase of Neurogenesis Are Associated with Therapeutic Improvement after Traumatic Brain Injury. J Neurotrauma. 25:130-139, 2008.
• Qu C, Mahmood A, Lu D, Goussev A, Xiong Y, Chopp M. Treatment of traumatic brain injury in mice with marrow stromal cells. Brain Res. 1208:234-239, 2008.
• Xiong Y, Mahmood A, Lu D, Qu C, Kazmi H, Goussev A, Zhang ZG, Noguchi CT, Schallert T, Chopp M. Histological and functional outcomes after traumatic brain injury in mice null for the erythropoietin receptor in the central nervous system. Brain Res. 1230:247-257, 2008.
• Xiong Y, Lu D, Qu C, Goussev A, Schallert T, Mahmood A, Chopp M. Effects of erythropoietin on reducing brain damage and improving functional outcome after traumatic brain injury in mice. J Neurosurg. 109:510-521, 2008.
• Wu H, Lu D, Jiang H, Xiong Y, Qu C, Li B, Mahmood A, Zhou D, Chopp M. Increase in phosphorylation of Akt and its downstream signaling targets and suppression of apoptosis by simvastatin after traumatic brain injury. J Neurosurg. 109:691-698, 2008.
• Gao J, Xiong Y, Ho YS, Liu X, Chua CC, Xu X, Wang H, Hamdy R, Chua BH. Glutathione peroxidase 1-deficient mice are more susceptible to doxorubicin-induced cardiotoxicity. Biochim Biophys Acta. 1783:2020-2029, 2008.
• Mahmood A, Goussev A, Lu D, Qu C, Xiong Y, Kazmi H, Chopp M. Long-Lasting Benefits after Treatment of Traumatic Brain Injury (TBI) in Rats with Combination Therapy of Marrow Stromal Cells (MSCs) and Simvastatin. J Neurotrauma. 25:1441-1447, 2008.
• Xiong Y, Mahmood A, Qu C, Liu Z, Ning R, Li Y, Lu D, Kaplan DL, Schallert T, Chopp M. Delayed transplantation of human marrow stromal cell-seeded scaffolds increases transcallosal neural fiber length, angiogenesis, and hippocampal neuronal survival and improves functional outcome after traumatic brain injury in rats. Brain Res. 1263:183-191, 2009.
• Zhang Y, Xiong Y, Mahmood A, Meng Y, Qu C, Schallert T, and Chopp M. Therapeutic effects of erythropoietin on histological and functional outcomes following traumatic brain injury in rats are independent of hematocrit. Brain Res. 1294:153-164, 2009.
• Qu C, Xiong Y, Mahmood A, Kaplan DL, Goussev A, Ning R, Chopp M. Treatment of traumatic brain injury in mice with bone marrow stromal cell-impregnated collagen scaffolds. J Neurosurg. 111:658-665, 2009.
• Xiong Y, Mahmood A, Qu C, Kazmi H, Zhang ZG, Noguchi CT, Kaplan DL, Schallert T, and Chopp M. Erythropoietin improves histological and functional outcomes after traumatic brain injury in mice in the absence of the neural erythropoietin receptor. J Neurotrauma 27: 205-215, 2010.
• Xiong Y, Mahmood A, Meng Y, Zhang Y, Qu C, Schallert T, and Chopp M. Delayed administration of erythropoietin reducing hippocampal cell loss, enhancing angiogenesis and neurogenesis, and improving functional outcome following traumatic brain injury in rats: comparison of treatment with single and triple dose. J Neurosurg 113: 598-608, 2010.
• Qu C, Mahmood A,, Ning R,, Xiong Y, Zhang L, Chen J, Jiang H, and Chopp H. The Treatment of Traumatic Brain Injury with Velcade. J Neurotrauma 27: 1625-1634, 2010.
• Zhang Y, Xiong Y, Mahmood A, Meng Y, Liu ZW, Qu C, and Chopp M. Sprouting of Corticospinal Tract Axons from the Contralateral Hemisphere into the Denervated Side of the Spinal Cord is Associated with Functional Recovery Following Traumatic Brain Injury and Erythropoietin Treatment in Adult Rat. Brain Res. 1353: 249-257, 2010.
• Xiong Y, Mahmood A, and Chopp M. Angiogenesis, neurogenesis and brain recovery of function after injury. Curr. Opin. Invest. Drugs. 11:298-308, 2010.
• Xiong Y, Mahmood, A, and Chopp M. Neurorestorative treatments for traumatic brain injury. Discovery Medicine 10: 434-442, 2010.
• Xiong Y, Mahmood A, Meng Y, Zhang Y, Zheng Gang Zhang ZG, Morris DC, and Chopp M. Treatment of traumatic brain injury with thymosin ?4 in rats. J Neurosurg. In Press 2010 May 21. [Epub ahead of print].
• Xiong Y, Mahmood A, Zhang Y, Meng Y, Zhang ZG, Qu C, Sager TN, and Chopp M. Effects of posttraumatic carbamylated erythropoietin therapy on reducing lesion volume and hippocampal cell loss, enhancing angiogenesis and neurogenesis, and improving functional outcome in rats following traumatic brain injury. J. Neurosurg. In Press 2010 Nov 12. [Epub ahead of print].
• Qu C, Mahmood A, Liu XS, Xiong Y, Wang L, Wu H, Li B, Zhang ZG, Kaplan DL, and Chopp M. The treatment of TBI with human marrow stromal cells impregnated into collagen scaffold: Functional outcome and gene expression profile. Brain Res. in Press 2010 Nov 6. [Epub ahead of print].